Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

@article{Ostapowicz2002ResultsOA,
  title={Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States},
  author={George Ostapowicz and Robert John Fontana and Frank Schidt and Anne M. Larson and Timothy J. Davern and Steven‐Huy B. Han and Timothy Mccashland and A. Obaid Shakil and J. Eileen Hay and Linda S. Hynan and Jeffrey S. Crippin and Andres T. Blei and Grace Samuel and Joan S. Reisch and William M. Lee},
  journal={Annals of Internal Medicine},
  year={2002},
  volume={137},
  pages={947-954}
}
Context Acute liver failure is a catastrophic condition affecting about 2000 persons in the United States each year. Contribution Among 308 consecutive patients with liver failure admitted to 1 of 17 referral centers between 1998 and 2001, acetaminophen overdose (39%) and idiosyncratic drug reactions (13%) were the most common cause of disease. Sixty-seven percent of patients were still living 3 weeks after presentation (44% without liver transplantation and 23% after transplantation). Survival… Expand

Paper Mentions

Observational Clinical Trial
The purpose of this study is to collect clinical and epidemiological data as well as serum, plasma, urine, tissue and DNA samples on individuals who have acute liver failure and on… Expand
ConditionsAcute Liver Failure, Acute Liver Injury, Fulminant Hepatic Failure
Observational Clinical Trial
The purpose of this study is to evaluate, through brief, one-on-one cognitive interviews, the efficacy of 'enhanced' acetaminophen messages and icons in improving consumer understanding… Expand
ConditionsAcetaminophen Overdose, Pain
InterventionBehavioral
Outcomes in Adults With Acute Liver Failure Between 1998 and 2013
TLDR
This large cohort study found that despite similar causes and severity of ALF among patients referred to specialty centers from 1998 to 2013, the proportion of patients listed for liver transplantation decreased and survival improved among those who did not receive a transplant as well asThose who did. Expand
Short and Long-Term Outcomes in Patients with Acute Liver Failure Due to Ischemic Hepatitis
TLDR
A higher admission serum phosphate level and more advanced encephalopathy are associated with a lower likelihood of short-term survival of hospitalized patients with ALF due to ischemic hepatitis. Expand
Etiologies and outcomes of acute liver failure in Germany.
  • J. Hadem, F. Tacke, +11 authors A. Canbay
  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2012
TLDR
In Germany, drug toxicity, indeterminate etiology, and viral hepatitis appear to be the major causes of primary ALF, which has high mortality and is at great risk of progressing to multiple organ failure. Expand
Acute liver failure.
TLDR
The causes and clinical manifestations of acute liver failure are outlined, current approaches to patient care are discussed, and rates of survival have improved substantially in recent years through advances in critical care management and the use of emergency liver transplantation. Expand
Acute liver failure.
TLDR
The causes and clinical manifestations of acute liver failure are outlined, current approaches to patient care are discussed, and rates of survival have improved substantially in recent years through advances in critical care management and the use of emergency liver transplantation. Expand
Efficacy of liver transplantation for acute hepatic failure: a single-center experience.
TLDR
Most patients with AHF, who fulfill the Kings College Criteria for LT, did not survive longer without LT, and currently, LT is still the most effective way to improve the prognosis of AHF patients. Expand
Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.
TLDR
To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors, a prospective, multicenter case study on children from birth to 18 years with ALF is conducted. Expand
Lessons from look-back in acute liver failure? A single centre experience of 3300 patients.
TLDR
The nature and outcome of ALF have transformed over 35 years, with major improvements in survival and a fall in prevalence of cerebral oedema and ICH, likely consequent upon earlier illness recognition, improved ICU care, and use of ELT. Expand
Acute liver failure: Summary of a workshop
TLDR
The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia, and poor prognosed with drug‐induced ALF, hepatitis B, and indeterminate cases, and excellent intensive care is critical in management of patients with ALF. Expand
Drug‐induced acute liver failure: Results of a U.S. multicenter, prospective study
TLDR
DILI is an uncommon cause of ALF that evolves slowly, affects a disproportionate number of women and minorities, and shows infrequent spontaneous recovery, but transplantation affords excellent survival. Expand
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