Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

@article{Ostapowicz2002ResultsOA,
  title={Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States},
  author={George Ostapowicz and Robert John Fontana and Frank Schidt and Anne M. Larson and Timothy J. Davern and Steven‐Huy B. Han and Timothy Mccashland and A. Obaid Shakil and J. Eileen Hay and Linda S. Hynan and Jeffrey S. Crippin and Andres T. Blei and Grace Samuel and Joan S. Reisch and William M. Lee},
  journal={Annals of Internal Medicine},
  year={2002},
  volume={137},
  pages={947-954}
}
Context Acute liver failure is a catastrophic condition affecting about 2000 persons in the United States each year. Contribution Among 308 consecutive patients with liver failure admitted to 1 of 17 referral centers between 1998 and 2001, acetaminophen overdose (39%) and idiosyncratic drug reactions (13%) were the most common cause of disease. Sixty-seven percent of patients were still living 3 weeks after presentation (44% without liver transplantation and 23% after transplantation). Survival… Expand
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1,870 Citations
Highly Influential Citations
74
Background Citations
527
Methods Citations
26
Results Citations
31

Paper Mentions

Observational Clinical Trial
A Multi-Center Trial to Study Acute Liver Failure in Adults
The purpose of this study is to collect clinical and epidemiological data as well as serum, plasma, urine, tissue and DNA samples on individuals who have acute liver failure and on… Expand
ConditionsAcute Liver Failure, Acute Liver Injury, Fulminant Hepatic Failure
University of Texas Southwestern Medical Center
January 1998 - August 2022
News Article
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5 April 2017
Observational Clinical Trial
Investigation of Efficacy of Improved Acetaminophen Labeling
The purpose of this study is to evaluate, through brief, one-on-one cognitive interviews, the efficacy of 'enhanced' acetaminophen messages and icons in improving consumer understanding… Expand
ConditionsAcetaminophen Overdose, Pain
InterventionBehavioral
Northwestern University
October 2012 - March 2013

1,870 Citations

Citation Type

Citation Type

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Acute liver failure.
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The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia, and poor prognosed with drug‐induced ALF, hepatitis B, and indeterminate cases, and excellent intensive care is critical in management of patients with ALF. Expand
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DILI is an uncommon cause of ALF that evolves slowly, affects a disproportionate number of women and minorities, and shows infrequent spontaneous recovery, but transplantation affords excellent survival. Expand
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