Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

@inproceedings{Iversen2017ResultsF1,
  title={Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly},
  author={Ane Bull Iversen and Michael Robert Horsman and Steen S Jakobsen and Jonas Brorson Jensen and Christian Garm and Niels Jessen and Peter Breining and J\orgen Fr\oki{\ae}r and Morten Busk},
  booktitle={Scientific Reports},
  year={2017}
}
The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation of hypoxia-induced radioresistance is gaining ground. Our… CONTINUE READING