Restriction sites containing CpG show a higher frequency of polymorphism in human DNA.

@article{Barker1984RestrictionSC,
  title={Restriction sites containing CpG show a higher frequency of polymorphism in human DNA.},
  author={David Barker and Matthias Schafer and R. White},
  journal={Cell},
  year={1984},
  volume={36 1},
  pages={131-8}
}
Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes, Msp I and Taq I, whose recognition… CONTINUE READING