Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases.

@article{Drrschuck2011RestrictionOP,
  title={Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases.},
  author={Eva Amarant D{\"o}rrschuck and Nicole Mercado Fischer and Ignacio G. Bravo and K Hanschmann and Heidi Johanna Kuiper and Andreas Sp{\"o}tter and Ronny M{\"o}ller and Klaus Cichutek and Carsten M{\"u}nk and Ralf R T{\"o}njes},
  journal={Journal of virology},
  year={2011},
  volume={85 8},
  pages={
          3842-57
        }
}
Xenotransplantation of porcine cells, tissues, and organs shows promise to surmount the shortage of human donor materials. Among the barriers to pig-to-human xenotransplantation are porcine endogenous retroviruses (PERV) since functional representatives of the two polytropic classes, PERV-A and PERV-B, are able to infect human embryonic kidney cells in vitro, suggesting that a xenozoonosis in vivo could occur. To assess the capacity of human and porcine cells to counteract PERV infections, we… CONTINUE READING

Citations

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Differential sensitivity of porcine endogenous retrovirus to APOBEC3-mediated inhibition

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