Corpus ID: 44975719

Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)).

@article{Sigel1975RestrictionOI,
  title={Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)).},
  author={H. Sigel and J. Janke and A. Fleckenstein},
  journal={Recent advances in studies on cardiac structure and metabolism},
  year={1975},
  volume={6},
  pages={
          121-6
        }
}
As shown in previous investigations overdoses of isoproterenol produce an abundant myocardial Ca uptake, followed by high energy phosphate breakdown, mitochondrial damage and, eventually, cardiac fibre necrotization. Conversely Ca antagonistic compounds such as verapamil, D 600 or prenylamine which reduce the transmembrane Ca influx into the heart muscle cells, can prevent high energy phosphate deficiency and cardiac lesions. Ethyl-4-(3,4,5-trimethoxycinnamoyl) poperazinyl acetate (Vascoril) is… Expand
3 Citations
Effects of verapamil on doxorubicin-induced mortality and electrolyte changes in the mouse heart.
TLDR
It is concluded from the findings of the present study that verapamil is inappropriate as an antagonist of the cardiac toxicity resulting from treatment with doxorubicin. Expand
The effects of diltiazem in dystrophic hamsters
TLDR
It is suggested that diltizem may have therapeutic value in those conditions that are accompanied by excessive accumulation of Ca in tissues, such as muscular dystrophy. Expand
Reperfusion injury. A possible link between catecholamine-induced and ischemic myocardial alterations.
TLDR
Changes in sarcolemmal membrane permeability suggest a direct cardiotoxic effect on myocardial lesions induced by catecholamines and coronary occlusion and reperfusion injuries in rats and morphological similarities suggest a common causal pathway for stress-induced and ischemic heart diseases. Expand