Restriction of foamy viruses by APOBEC cytidine deaminases.

@article{Delebecque2006RestrictionOF,
  title={Restriction of foamy viruses by APOBEC cytidine deaminases.},
  author={Fr{\'e}d{\'e}ric Delebecque and Rodolphe Susp{\`e}ne and Sara Calattini and Nicoletta Casartelli and Ali Sa{\"i}b and Alain Froment and Simon Wain-Hobson and Antoine Gessain and J P Vartanian and Olivier Schwartz},
  journal={Journal of virology},
  year={2006},
  volume={80 2},
  pages={605-14}
}
Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV. We show that human APOBEC3G is a potent inhibitor of FV infectivity in cell culture experiments. This antiviral activity is associated with cytidine editing of the viral genome. Both molecular… CONTINUE READING

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APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast.

Proceedings of the National Academy of Sciences of the United States of America • 2005

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Proceedings of the National Academy of Sciences of the United States of America • 2005

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