Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral Protein

@article{Kaiser2007RestrictionOA,
title={Restriction of an Extinct Retrovirus by the Human TRIM5$\alpha$ Antiviral Protein},
author={Shari M. Kaiser and Harmit S. Malik and Michael Emerman},
journal={Science},
year={2007},
volume={316},
pages={1756 - 1758}
}
• Published 22 June 2007
• Biology
• Science
Primate genomes contain a large number of endogenous retroviruses and encode evolutionarily dynamic proteins that provide intrinsic immunity to retroviral infections. We report here the resurrection of the core protein of a 4-million-year-old endogenous virus from the chimpanzee genome and show that the human variant of the intrinsic immune protein TRIM5α can actively prevent infection by this virus. However, we suggest that selective changes that have occurred in the human lineage during the…
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