Restriction of Intravenous Fluid in ICU Patients with Septic Shock.

  title={Restriction of Intravenous Fluid in ICU Patients with Septic Shock.},
  author={Tine Sylvest Meyhoff and Peter Buhl Hjortrup and J{\o}rn Wetterslev and Praleene Sivapalan and Jon Henrik Laake and Maria Cronhjort and Stephan M. Jakob and Maurizio Cecconi and Marek Nalos and Marlies Ostermann and Manu L. N. G. Malbrain and Ville Pettil{\"a} and Morten Hylander M{\o}ller and Maj‐Brit N{\o}rregaard Kj{\ae}r and Theis Lange and Christian Overgaard-Steensen and Bj{\"o}rn Anders Brand and Marie Winther‐Olesen and Jonathan O White and Lars Quist and Bo Westergaard and Andreas Bender Jonsson and Carl Johan Steensen Hjorts{\o} and Nick Meier and Thomas Steen Jensen and Janus Engstr{\o}m and Lars Nebrich and Nina Christine Andersen-Ranberg and Jacob V Jensen and Neeliya A Joseph and Lone M. Poulsen and Louise S Herl{\o}v and Christoffer Grant S{\o}lling and Susan K Pedersen and Kurt Krogh Knudsen and Therese Simonsen Straarup and Marianne Lauridsen Vang and Helle Bundgaard and Bodil Steen Rasmussen and S{\o}ren Rosborg Aagaard and Thomas Hildebrandt and Lene Russell and Morten H. Bestle and Martin Sch{\o}nemann-Lund and Anne C Br{\o}chner and Claes Falkenberg Elvander and S{\o}ren K L Hoffmann and Michael L Rasmussen and Yvonne K Martin and F Friberg and Herman Seter and Tayyba Naz Aslam and Sigrid {\AA}dn{\o}y and Philipp Seidel and Kristian Strand and Bror Johnstad and Eva Joelsson-Alm and Jens Christensen and Christian Ahlstedt and Carmen Andrea Pfortmueller and Martin Siegemund and Massimiliano Greco and Jaroslav Raděj and Miroslav Kř{\'i}{\vz} and Doug W. Gould and Kathy Rowan and Paul R. Mouncey and Anders Perner},
  journal={The New England journal of medicine},
BACKGROUND Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU). METHODS In this international, randomized trial, we assigned patients with septic shock in the ICU who had received at least 1 liter of intravenous fluid to receive restricted intravenous fluid or standard intravenous fluid therapy; patients were included if the onset of shock had been… 

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