Restriction map of a YAC and cosmid contig encompassing the oculopharyngeal muscular dystrophy candidate region on chromosome 14q11.2-q13.

@article{Xie1998RestrictionMO,
  title={Restriction map of a YAC and cosmid contig encompassing the oculopharyngeal muscular dystrophy candidate region on chromosome 14q11.2-q13.},
  author={Yu Guang Xie and Daniel L. Rochefort and Bernard Brais and Holly A. Howard and Fu You Han and Lantu Gou and Patr{\'i}cia Maciel and B T The and Catharina Larsson and Guy A Rouleau},
  journal={Genomics},
  year={1998},
  volume={52 2},
  pages={
          201-4
        }
}
As part of our effort to clone positionally the oculopharyngeal muscular dystrophy (OPMD) gene, we constructed a YAC contig, a cosmid contig, and an EcoRI restriction map of the OPMD candidate region. The YAC contig spans more than 2 Mb and encompasses the loci D14S283 and D14S990 and the cardiac alpha and beta myosin heavy chain genes (MYH6 and MYH7). A 700-kb cosmid contig containing the D14S990 and the myosin genes and a long-range restriction map covering the region between D14S990 and the… CONTINUE READING
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