Restriction fragment length polymorphisms for the renin gene in Dahl rats.

@article{Dene1989RestrictionFL,
  title={Restriction fragment length polymorphisms for the renin gene in Dahl rats.},
  author={Howard Dene and San Ming Wang and John P. Rapp},
  journal={Journal of hypertension},
  year={1989},
  volume={7 2},
  pages={
          121-6
        }
}
Genomic DNAs from inbred Dahl salt-hypertension sensitive (S) and inbred Dahl salt-hypertension resistant (R) rats were examined for restriction fragment length polymorphisms (RFLPs) using a rat renin cDNA probe. Eight of the 28 restriction enzymes used yielded polymorphic fragments between S and R strains. This suggests a major structural difference in or near the renin gene of Dahl rats. Some, but not all, of the polymorphisms are compatible with an insertion/deletion mutation of about 1.1 kb… CONTINUE READING
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