Restriction fragment length polymorphism typing of clinical isolates of Mycobacterium tuberculosis from patients with pulmonary tuberculosis in Madras, India, by use of direct-repeat probe.

@article{Sahadevan1995RestrictionFL,
  title={Restriction fragment length polymorphism typing of clinical isolates of Mycobacterium tuberculosis from patients with pulmonary tuberculosis in Madras, India, by use of direct-repeat probe.},
  author={R Sahadevan and Sujatha Narayanan and Chinnampedu N. Paramasivan and Raj Prabhakar and P. R. Narayanan},
  journal={Journal of clinical microbiology},
  year={1995},
  volume={33 11},
  pages={3037-9}
}
Large numbers of Mycobacterium tuberculosis isolates that were obtained from patients' sputa on diagnosis and during follow-up after short-course chemotherapy in Madras, India, have either no copy or only a single copy of IS6110. This poses a limitation for DNA fingerprinting with an IS6110-based probe to determine the frequency of exogenous reinfection versus that of endogenous reactivation. In the present study, we overcame this limitation by using an alternate probe, the direct-repeat… CONTINUE READING

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