Restriction fragment length polymorphism (RFLP) analysis in the TNF genes of patients with systemic lupus erythematosus (SLE).

@article{Tomita1993RestrictionFL,
  title={Restriction fragment length polymorphism (RFLP) analysis in the TNF genes of patients with systemic lupus erythematosus (SLE).},
  author={Yoshihiko Tomita and Shoji Hashimoto and Keigo Yamagami and Shigemasa Sawada and Takashi Horie},
  journal={Clinical and experimental rheumatology},
  year={1993},
  volume={11 5},
  pages={
          533-6
        }
}
Although systemic lupus erythematosus (SLE) is known to be positively associated with certain major histocompatibility complex (MHC) class I and/or class II antigens, it is not clear whether the MHC genes are the predisposing genes of the disease rather than markers for other closely linked gene(s). Because of the involvement of tumor necrosis factor (TNF) in the inflammation process and localization of the TNF genes in the proximity of the HLA-B locus, we studied the restriction fragment… CONTINUE READING