Restriction factors: a defense against retroviral infection.

  title={Restriction factors: a defense against retroviral infection.},
  author={Paul D Bieniasz},
  journal={Trends in microbiology},
  volume={11 6},
Susceptibility to retroviral infection is determined, in part, by host genes with antiviral activity. The Fv1 gene, which inhibits murine leukemia virus infection in mice, encodes one such resistance factor, and was long thought to be unique in that it restricts post-entry, pre-integration steps of retroviral replication. However, recent findings suggest the existence of similar restriction factors in primates, including humans. These factors, termed Lv1 and Ref1, can inhibit a range of… CONTINUE READING