Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes

@article{Zinkernagel1974RestrictionBH,
  title={Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes},
  author={Rolf Martin Zinkernagel},
  journal={Nature},
  year={1974},
  volume={251},
  pages={230-233}
}
RESULTS from three distinct experimental systems indicate that, except for lymphocytes reacting to alloantigens, interaction between sensitised thymus-derived lymphocytes (T cells) and other somatic cells occurs only in syngeneic or semiallogeneic systems. First, histoincompatible T cells do not function as helpers for antibody-forming cell precursors (B cells)1,2. Second, maximal proliferation of lymphocytes (presumably T cells) resulting from exposure in vitro of sensitised guinea pig… CONTINUE READING