Restriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins

@inproceedings{Hargreaves2014RestrictionAR,
  title={Restriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins},
  author={Adam D. Hargreaves and Martin T. Swain and Matthew J. Hegarty and Darren W. Logan and John Frederick Mulley},
  booktitle={Genome biology and evolution},
  year={2014}
}
Snake venom has been hypothesized to have originated and diversified through a process that involves duplication of genes encoding body proteins with subsequent recruitment of the copy to the venom gland, where natural selection acts to develop or increase toxicity. However, gene duplication is known to be a rare event in vertebrate genomes, and the recruitment of duplicated genes to a novel expression domain (neofunctionalization) is an even rarer process that requires the evolution of novel… CONTINUE READING
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