Restriction Landmark Genomic Scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations

@article{Smiraglia2007RestrictionLG,
  title={Restriction Landmark Genomic Scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations},
  author={Dominic J. Smiraglia and Ramakrishnan Kazhiyur-Mannar and Christopher C. Oakes and Yue-zhong Wu and Ping Liang and Tahmina Ansari and Jian Su and Laura J. Rush and Laura T. Smith and Li Yu and Chunhui Liu and Zunyan Dai and Shih-Shih Chen and Shu-Huei Wang and Joseph F. Costello and I. Ioshikhes and David W. Dawson and Jason S. Hong and Michael A Teitell and Angela Szafranek and Marta Camoriano and Fei Song and Rosemary W. Elliott and W. Held and Jacquetta M. Trasler and Christoph Plass and Rephael Wenger},
  journal={BMC Genomics},
  year={2007},
  volume={8},
  pages={446 - 446}
}
Restriction landmark genomic scanning (RLGS) is one of the most successfully applied methods for the identification of aberrant CpG island hypermethylation in cancer, as well as the identification of tissue specific methylation of CpG islands. However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning." We report the development of a virtual RLGS method (vRLGS) that allows for… CONTINUE READING

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