Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window.

@article{Zhao2002RestrictingTS,
  title={Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window.},
  author={Xilin Zhao and Karl Drlica},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 4},
  pages={561-5}
}
The selection of antibiotic-resistant mutant bacteria is proposed to occur in a drug concentration range (the mutant selection window) that extends from the minimum inhibitory concentration (MIC) of susceptible cells to the MIC of the least susceptible, single-step bacterial mutants (the mutant prevention concentration [MPC]). MPCs were estimated for tobramycin, chloramphenicol, rifampicin, penicillin, vancomycin, and several fluoroquinolones by use of Escherichia coli and Staphylococcus aureus… CONTINUE READING

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References

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Showing 1-10 of 15 references

February) netics of intravenous chloramphenicol sodium succinate in adult patients with normal renal and hepatic function

  • J Burke, W Wargin, +4 authors Drlica
  • JID
  • 2002
1 Excerpt

Pharmacokinetic profiles of high-dose intravenous ciprofloxacin in severe sepsis

  • J Lippman, J Scribante, AG Gous, H Hon, S. Tshukutsoane
  • Antimicrob Agents Chemother
  • 1998
2 Excerpts

The epidemiology of bacterial resistance to antimicrobial agents

  • F Tenover, JE McGowan
  • 1998
1 Excerpt

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