Restricting Microbial Exposure in Early Life Negates the Immune Benefits Associated with Gut Colonization in Environments of High Microbial Diversity

@inproceedings{Mulder2011RestrictingME,
  title={Restricting Microbial Exposure in Early Life Negates the Immune Benefits Associated with Gut Colonization in Environments of High Microbial Diversity},
  author={Imke E Mulder and Bettina Schmidt and Marie C. Lewis and Margaret I. Delday and Christopher R. Stokes and Mick Bailey and Rustam I. Aminov and Bhupinder Pal Gill and John R. Pluske and C Mayer and Denise Kelly},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Acquisition of the intestinal microbiota in early life corresponds with the development of the mucosal immune system. Recent work on caesarean-delivered infants revealed that early microbial composition is influenced by birthing method and environment. Furthermore, we have confirmed that early-life environment strongly influences both the adult gut microbiota and development of the gut immune system. Here, we address the impact of limiting microbial exposure after initial… CONTINUE READING
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