Restricted usage of T-cell receptor Valpha-Vbeta genes in infiltrating cells in the aortic tissue of a patient with atherosclerotic aortic aneurysm.

@article{Seko1998RestrictedUO,
  title={Restricted usage of T-cell receptor Valpha-Vbeta genes in infiltrating cells in the aortic tissue of a patient with atherosclerotic aortic aneurysm.},
  author={Yoshinori Seko and Nobuki Takahashi and Osamu Sato and Atsuhiko Takagi and Hideo Yagita and Katsuhiko Okumura and Yoshio Yazaki},
  journal={International angiology : a journal of the International Union of Angiology},
  year={1998},
  volume={17 2},
  pages={
          89-92
        }
}
We report a rare case of an atherosclerotic aortic aneurysm with lymphocyte infiltration in which T-cell receptor (TCR) Valpha as well as Vbeta gene usage was restricted. Immunohistochemical studies showed that the infiltrating cells mainly consisted of macrophages, natural killer (NK) cells, cytotoxic T lymphocytes (CTLs) and T-helper (Th) cells, and that there were almost no infiltrating delta T lymphocytes, and human leukocyte antigen (HLA) class I and 65-kD heat-shock protein (HSP-65) was… CONTINUE READING