Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination.

Abstract

One-third of humans are infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. Sequence analysis of two megabases in 26 structural genes or loci in strains recovered globally discovered a striking reduction of silent nucleotide substitutions compared with other human bacterial pathogens. The lack of neutral mutations in structural… (More)

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@article{Sreevatsan1997RestrictedSG, title={Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination.}, author={Srinand Sreevatsan and X. Pan and Kathryn E. Stockbauer and Nancy D. Connell and B. N. Kreiswirth and Thomas S. Whittam and J. M. Musser}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1997}, volume={94 18}, pages={9869-74} }