Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases.

@article{Meij1999RestrictedLH,
  title={Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases.},
  author={Pauline Meij and Marcel B H J Vervoort and Jamil Aarbiou and P van Dissel and A. F. Ten Brink and Elisabeth Bloemena and Chris J L M Meijer and Jaap M Middeldorp},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={179 5},
  pages={1108-15}
}
Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)-related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt… CONTINUE READING

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