Restricted idiotypic profile of anti-phosphorylcholine antibodies induced by carrier-specific helper T cell clones.

Abstract

The primary antibody response of C57BL/6 mice to phosphorylcholine (PC) is dominated by immunoglobulins of the T15 idiotype family. Using monoclonal antibodies that define individual idiotopes (Id) of T15, it has been shown that the antibody plaque-forming cells (PFC) arise from heterogeneous population of B cells that may express some but not all T15 Id… (More)

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