Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT.

@article{Inwald2018RestrictedFB,
  title={Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT.},
  author={David Philip Inwald and Ruth R Canter and Kerry Woolfall and Caitlin B O'Hara and P Mouncey and Zohra Zenasni and N. E. Hudson and Steven Saunders and Anjali Carter and Nicola Jones and Mark D Lyttle and Simon Nadel and Mark J. Peters and David A Harrison and Kathryn M. Rowan},
  journal={Health technology assessment},
  year={2018},
  volume={22 51},
  pages={
          1-106
        }
}
BACKGROUND There has been no randomised controlled trial (RCT) of fluid bolus therapy in paediatric sepsis in the developed world despite evidence that excess fluid may be associated with harm. OBJECTIVES To determine the feasibility of the Fluids in Shock (FiSh) trial - a RCT comparing restricted fluid bolus (10 ml/kg) with current practice (20 ml/kg) in children with septic shock in the UK. DESIGN (1) Qualitative feasibility study exploring parents' views about the pilot RCT. (2) Pilot… CONTINUE READING
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