Restricted diversity of V gamma 9-JP rearrangements in unstimulated human gamma/delta T lymphocytes.

@article{Delfau1992RestrictedDO,
  title={Restricted diversity of V gamma 9-JP rearrangements in unstimulated human gamma/delta T lymphocytes.},
  author={Marie H{\'e}l{\`e}ne Delfau and Allan J. Hance and Denise Lecossier and Etienne Vilmer and Bernard Grandchamp},
  journal={European journal of immunology},
  year={1992},
  volume={22 9},
  pages={2437-43}
}
The diversity of human peripheral blood gamma/delta T cells is known to be limited by the preferential use of V genes coding for V gamma 9 (usually linked to JP) and V delta 2. We show that the diversity of these cells is further limited at the junctional region. First, an identical rearrangement is found in 10%-30% of all gamma/delta T cells which contain V gamma 9-JP rearrangements. Second, the vast majority of V gamma 9-JP rearrangements which are different from this predominant sequence… CONTINUE READING

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