Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis.

  title={Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis.},
  author={Thomas Mueggler and Melanie Meyer-Luehmann and Martin Rausch and Matthias Staufenbiel and Mathias Jucker and Markus Rudin},
  journal={The European journal of neuroscience},
  volume={20 3},
A prominent hallmark of Alzheimer's disease pathology is cerebral amyloidosis. However, it is not clear how extracellular amyloid-beta peptide (A beta) deposition and amyloid formation compromise brain function and lead to dementia. It has been argued that extracellular amyloid deposition is neurotoxic and/or that soluble A beta oligomers impair synaptic function. Amyloid deposits, by contrast, may affect diffusion properties of the brain interstitium with implications for the transport of… CONTINUE READING


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