Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA.

Abstract

The production of inflammatory cytokines from macrophages (Mphi), upon stimulation with plasmid DNA (pDNA) containing CpG motifs, is a critical process for DNA-based therapies such as DNA vaccination and gene therapy. We compared Mphi activation, following stimulation with naked pDNA, based on the production of cytokines from cell lines (RAW264.7 and J774A1… (More)

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Cite this paper

@article{Yasuda2004RestrictedCP, title={Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA.}, author={Kei Yasuda and Hiroki Kawano and Ikuko Yamane and Yoshiyuki Ogawa and Takaharu Yoshinaga and Makiya Nishikawa and Yoshinobu Takakura}, journal={Immunology}, year={2004}, volume={111 3}, pages={282-90} }