Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+ T cells in allogeneic bone marrow transplantation recipients.

@article{Vavassori1996RestrictedTR,
  title={Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+ T cells in allogeneic bone marrow transplantation recipients.},
  author={Mauro Vavassori and Rita Maccario and Alessandro Moretta and Patrizia Comoli and Andreas Wack and Franco Locatelli and Antonio Lanzavecchia and Emanuela Maserati and Paolo Dellabona and Giulia Casorati and Daniela Montagna},
  journal={Journal of immunology},
  year={1996},
  volume={157 12},
  pages={5739-47}
}
We investigated the contribution of transfer of Ag-experienced donor T cells to the immune reconstitution of allogeneic bone marrow transplantation (BMT) recipients. To this purpose, we used a combination of cell culture methods to isolate tetanus toxoid (TT)-specific T cell clones, and a sensitive and specific heteroduplex analysis to monitor the presence of a particular clonotype using TCR N region sequences. We document that patients after BMT display a small response to TT, entirely… CONTINUE READING