Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.

@article{Brod1991RestrictedTC,
  title={Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.},
  author={Staley Armstrong Brod and D D Benjamin and David A. Hafler},
  journal={Journal of immunology},
  year={1991},
  volume={147 3},
  pages={810-5}
}
It has been difficult to demonstrate functionally distinct T cell populations in humans on the basis of cytokine secretion. As previous investigators have examined the T cell cytokine profile from immunized animals, we examined whether Th1 or Th2 type T cells could be identified in the peripheral blood or cerebrospinal fluid (CSF) immune compartments from subjects with or without inflammatory diseases. Using limiting dilution analysis and growth with PHA and IL-2/IL-4, we directly cloned a… CONTINUE READING
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