Restricted Presence of the Growth Hormone-Releasing Hormone Receptor to Somatotropes in Rat and Human Pituitaries

  title={Restricted Presence of the Growth Hormone-Releasing Hormone Receptor to Somatotropes in Rat and Human Pituitaries},
  author={Gérard Morel and Rosal{\'i}a Gallego and Luce Boulanger and Elena Pintos and Tom{\'a}s Garc{\'i}a-Caballero and Pierrette Gaudreau},
  pages={128 - 136}
Specific binding of growth hormone-releasing hormone (GHRH) to its plasma membrane receptor represents the first step of cellular signals leading to exocytotic GH secretion in the anterior pituitary. The GHRH receptor (GHRH-R) has been cloned and belongs to the secretin/glucagon/vasoactive intestinal peptide subfamilly of G-protein-coupled receptors. To study its characteristics in rat and human pituitaries and examine its cellular and subcellular localization, a site-directed polyclonal… 

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  • Biology, Medicine
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  • 1992
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