Restricted Presence of the Growth Hormone-Releasing Hormone Receptor to Somatotropes in Rat and Human Pituitaries
@article{Morel1999RestrictedPO, title={Restricted Presence of the Growth Hormone-Releasing Hormone Receptor to Somatotropes in Rat and Human Pituitaries}, author={Gérard Morel and Rosal{\'i}a Gallego and Luce Boulanger and Elena Pintos and Tom{\'a}s Garc{\'i}a-Caballero and Pierrette Gaudreau}, journal={Neuroendocrinology}, year={1999}, volume={70}, pages={128 - 136} }
Specific binding of growth hormone-releasing hormone (GHRH) to its plasma membrane receptor represents the first step of cellular signals leading to exocytotic GH secretion in the anterior pituitary. The GHRH receptor (GHRH-R) has been cloned and belongs to the secretin/glucagon/vasoactive intestinal peptide subfamilly of G-protein-coupled receptors. To study its characteristics in rat and human pituitaries and examine its cellular and subcellular localization, a site-directed polyclonal…
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References
SHOWING 1-10 OF 47 REFERENCES
Cellular localization of the growth hormone receptor/binding protein in the human anterior pituitary gland.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 1995
The presence of GH receptor/binding protein (GHR/BP) in discrete human pituitary cells and indicate a paracrine, autocrine, or intracrine role for GH in the pituitaries are demonstrated.
Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.
- Biology, MedicineMolecular endocrinology
- 1993
The cloning of a cDNA encoding a human GHRH-R from an acromegalic pituitary cDNA library is reported, which is a member of the secretin family of G-protein-coupled receptors and has 47%, 42%, 35%, and 28% identity with receptors for vasoactive intestinal peptide, secretin, calcitonin, and PTH, respectively.
Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.
- Biology, MedicineMolecular endocrinology
- 1992
A mechanism for cellular signaling by GHRH is defined and the opportunity to examine the role of the G HRH receptor in growth abnormalities that involve the GH axis is provided.
Structure, Function, and Regulation of the Pituitary Receptor for Growth Hormone Releasing Hormone
- Biology, Medicine
- 1996
An important role for GHRH in body growth is suggested both by clinical studies with G HRH-producing tumors, and by animal studies withGHRH-expressing transgenes; in both cases growth hormone hypersecretion, pituitary somatotroph hyperplasia, and inappropriate growth are observed.
Ultrastructural evidence for endogenous growth hormone-releasing factor-like immunoreactivity in the monkey pituitary gland.
- Biology, MedicineNeuroendocrinology
- 1984
Growth hormone-releasing factor-like immunoreactivity was visualized in monkey pituitary gland by immunocytochemistry on ultrathin sections obtained by cryoultramicrotomy and cytological evidence for direct participation of growth hormone- releasing factor in the regulation of the somatotropic function was provided.
Prolactin receptor immunoreactivity in rat anterior pituitary.
- Biology, MedicineNeuroendocrinology
- 1994
The identification of receptors specific to PRL within different cells of the anterior pituitsary raises the interesting possibility that PRL may act via an autocrine or paracrine network in regulating anterior pituitary function.
Growth hormone releasing hormone receptors on thymocytes and splenocytes from rats.
- Biology, MedicineCellular immunology
- 1991
Cross-linking of a growth hormone releasing factor-binding protein in anterior pituitary cells.
- BiologyThe Journal of biological chemistry
- 1986
Development of a Site-Directed Polyclonal Antibody against the Pituitary Growth Hormone-Releasing Hormone Receptor and Its Use to Estimate GHRH Receptor Concentration in Normal and Hypothyroid Rats
- Biology, MedicineNeuroendocrinology
- 1999
The characteristics of the anti-GHRH-R(392–404) polyclonal antibody indicate that it specifically recognizes the human and rat GHRH -R and represents an additional valuable tool to estimate variations of G HRH-Rs in physiopathological conditions known to affect GHRh-R mRNA and/or GHR h binding site concentrations.
Uptake and ultrastructural localization of a [125I] growth hormone releasing factor agonist in male rat pituitary gland: evidence for internalization.
- BiologyEndocrinology
- 1991
The findings show the cellular specificity of GRF uptake by somatotrophs and the internalization process from the plasma membrane to the intracellular organelles (secretory granules, lysosomes, and nuclear membrane) and the appearance of label on the nuclear membrane suggests that GRF may have effects on the translocation of messenger RNA from nucleus to cytoplasm in somatosomes.