Restricted Immunoglobulin Variable Region (Ig V) Gene Expression Accompanies Secondary Rearrangements of Light Chain Ig V Genes in Mouse Plasmacytomas

@article{Diaw1999RestrictedIV,
  title={Restricted Immunoglobulin Variable Region (Ig V) Gene Expression Accompanies Secondary Rearrangements of Light Chain Ig V Genes in Mouse Plasmacytomas},
  author={Lena Diaw and David Siwarski and Allen E Coleman and Jennifer Kim and Gary M. Jones and Guillaume Dighiero and Konrad E. Huppi},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={190},
  pages={1405 - 1416}
}
The many binding studies of monoclonal immunoglobulin (Ig) produced by plasmacytomas have found no universally common binding properties, but instead, groups of plasmacytomas with specific antigen-binding activities to haptens such as phosphorylcholine, dextrans, fructofuranans, or dinitrophenyl. Subsequently, it was found that plasmacytomas with similar binding chain specificities not only expressed the same idiotype, but rearranged the same light (V(L)) and heavy (V(H)) variable region genes… CONTINUE READING