Restricted Genetic Diversity of HIV-1 Subtype C Envelope Glycoprotein from Perinatally Infected Zambian Infants

@inproceedings{Zhang2010RestrictedGD,
  title={Restricted Genetic Diversity of HIV-1 Subtype C Envelope Glycoprotein from Perinatally Infected Zambian Infants},
  author={Hong Zhang and Damien C. Tully and Federico Guillermo Hoffmann and Jun He and Chipepo Kankasa and Charles Wood},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Mother-to-child transmission of HIV-1 remains a significant problem in the resource-constrained settings where anti-retroviral therapy is still not widely available. Understanding the earliest events during HIV-1 transmission and characterizing the newly transmitted or founder virus is central to intervention efforts. In this study, we analyzed the viral env quasispecies of six mother-infant transmission pairs (MIPs) and characterized the genetic features of envelope glycoprotein… CONTINUE READING