Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats.

@article{Goebel2009RestraintSA,
  title={Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats.},
  author={Miriam Goebel and Andreas Stengel and Lixin Wang and Yvette F. Tach{\'e}},
  journal={Brain research},
  year={2009},
  volume={1300},
  pages={114-24}
}
Nesfatin-1 is a newly discovered peptide that was reported to reduce food intake when injected centrally. We recently described its wide distribution in rat brain autonomic nuclei which implies potential recruitment of nesfatin-1 by stress. We investigated whether restraint, a mixed psychological and physical stressor, activates nesfatin-1-immunoreactive (ir) neurons in the rat brain. Male Sprague-Dawley rats were either subjected to 30 min restraint or left undisturbed and 90 min later brains… CONTINUE READING