Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6.

@article{Lin2005RestraintOB,
  title={Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6.},
  author={Ling Lin and Steven L Brody and Stanford L. Peng},
  journal={Journal of immunology},
  year={2005},
  volume={175 2},
  pages={951-8}
}
The forkhead transcription factor Foxj1 inhibits spontaneous autoimmunity, in part by antagonizing NF-kappaB activation in T cells. We demonstrate here that Foxj1 also inhibits humoral immune responses intrinsically in B cells; Foxj1 deficiency in B cells results in spontaneous and accentuated germinal center formation, associated with the development of pathogenic autoantibodies and accentuated responses to immunizations-all reflecting excessive activity of NF-kappaB and its target gene IL-6… CONTINUE READING
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