Restraint-induced hypoactivity in an elevated plus-maze.

@article{Padovan2000RestraintinducedHI,
  title={Restraint-induced hypoactivity in an elevated plus-maze.},
  author={Cl{\'a}udia Maria Padovan and Francisco S Guimar{\~a}es},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2000},
  volume={33 1},
  pages={79-83}
}
Rodents submitted to restraint stress show decreased activity in an elevated plus-maze (EPM) 24 h later. The objective of the present study was to determine if a certain amount of time is needed after stress for the development of these changes. We also wanted to verify if behavioral tolerance of repeated daily restraint would be detectable in this model. Male Wistar rats were restrained for 2 h and tested in the EPM 1, 2, 24 or 48 h later. Another group of animals was immobilized daily for 2 h… CONTINUE READING

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