Restraining mycobacteria: Role of granulomas in mycobacterial infections

@article{Saunders2000RestrainingMR,
  title={Restraining mycobacteria: Role of granulomas in mycobacterial infections},
  author={Bernadette M Saunders and Andrea M. Cooper},
  journal={Immunology and Cell Biology},
  year={2000},
  volume={78}
}
The generation of prolonged immunity to Mycobacterium tuberculosis requires not only an antigen‐specific IFN‐γ‐producing T cell response, including both CD4 and CD8 T cells, but also the generation of protective granulomatous lesions, whereby the close apposition of activated T cells and macrophages acts to contain bacterial growth. The importance of the granulomatous lesion in controlling this immune response and in limiting both tissue damage and bacterial dissemination has been considered a… 
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