Restoring voluntary control of locomotion after paralyzing spinal cord injury.

  title={Restoring voluntary control of locomotion after paralyzing spinal cord injury.},
  author={Rubia van den Brand and Janine Heutschi and Quentin Barraud and Jack DiGiovanna and Kay Bartholdi and Mich{\`e}le Huerlimann and Lucia Friedli and Isabel Vollenweider and Eduardo Martin Moraud and S. E. J. Duis and Nadia Dominici and Silvestro Micera and Pavel Musienko and Gr{\'e}goire Courtine},
  volume={336 6085},
Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions. Despite the interruption of direct supraspinal pathways, the cortex regained the capacity to transform contextual information into task-specific commands to execute refined locomotion. This recovery relied on the extensive remodeling of cortical projections… CONTINUE READING
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