Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

@article{Nygaard2020RestoringSH,
  title={Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes},
  author={Gyrid Nygaard and G. Firestein},
  journal={Nature Reviews Rheumatology},
  year={2020},
  volume={16},
  pages={316-333}
}
  • Gyrid Nygaard, G. Firestein
  • Published 2020
  • Medicine
  • Nature Reviews Rheumatology
  • Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the synovium of diarthrodial joints. During the course of RA, the synovium transforms into a hyperplastic invasive tissue that causes destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS), which form the lining of the joint, are epigenetically imprinted with an aggressive phenotype in RA and have an important role in these pathological processes. In addition to producing the extracellular… CONTINUE READING
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