Restoring function in exhausted CD8 T cells during chronic viral infection

@article{Barber2006RestoringFI,
  title={Restoring function in exhausted CD8 T cells during chronic viral infection},
  author={Daniel L. Barber and E. John Wherry and David Masopust and Baogong Zhu and James P. Allison and Arlene H. Sharpe and Gordon J. Freeman and Rafi Ahmed},
  journal={Nature},
  year={2006},
  volume={439},
  pages={682-687}
}
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analysed genes expressed in functionally impaired virus-specific CD8 T cells present in mice chronically infected with lymphocytic choriomeningitis virus (LCMV), and compared these with the gene profile of functional memory CD8 T cells. Here we report that PD-1 (programmed death 1… 
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