Restoring function in exhausted CD8 T cells during chronic viral infection

@article{Barber2006RestoringFI,
  title={Restoring function in exhausted CD8 T cells during chronic viral infection},
  author={Daniel L. Barber and Elaine Wherry and David Masopust and Baogong Zhu and James P Allison and Arlene H Sharpe and Gordon J Freeman and Rafi Ahmed},
  journal={Nature},
  year={2006},
  volume={439},
  pages={682-687}
}
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analysed genes expressed in functionally impaired virus-specific CD8 T cells present in mice chronically infected with lymphocytic… CONTINUE READING