Restoring force development by titin/connectin and assessment of Ig domain unfolding

Abstract

Titin/connectin is the main determinant of physiological levels of passive muscle force. This force is generated by the extensible I-band region of the molecule, which is composed of serially-linked immunoglobulin (Ig)-like domains and several unique sequence elements. Here we address the role of titin/connectin in sarcomeres shortened to below the slack… (More)
DOI: 10.1007/s10974-005-9037-2

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