Restored immunosuppressive effect of mesenchymal stem cells on B cells after olfactory 1/early B cell factor-associated zinc-finger protein down-regulation in patients with systemic lupus erythematosus.

@article{Feng2014RestoredIE,
  title={Restored immunosuppressive effect of mesenchymal stem cells on B cells after olfactory 1/early B cell factor-associated zinc-finger protein down-regulation in patients with systemic lupus erythematosus.},
  author={Xuebing Feng and Nan Che and Yan Liu and Hai-Feng Chen and Dandan Wang and Xia Chong Li and Weiwei Chen and Xiaolei Ma and Bingzhu Hua and Xiang Gao and Betty P. Tsao and Lingyun Sun},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 12},
  pages={3413-23}
}
OBJECTIVE To evaluate whether olfactory 1/early B cell factor-associated zinc-finger protein (OAZ), a candidate lupus susceptibility gene involved in antinuclear antibody (ANA) production, plays a role in the regulation of B cells by mesenchymal stem cells (MSCs). METHODS MSCs derived from the bone marrow of patients with systemic lupus erythematosus (SLE) and healthy control subjects were expanded and incubated with small interfering RNAs specific for OAZ or a nontargeting sequence… CONTINUE READING