Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.

Abstract

BACKGROUND & AIMS In patients with chronic hepatitis B virus (HBV) infection, persistent exposure to high concentrations of antigen can disrupt T-cell functions. It is not clear to what extent long-term suppression of HBV by nucleos(t)ide analogues can restore antiviral T-cell functions. We compared HBV-specific T-cell responses of patients treated with… (More)
DOI: 10.1053/j.gastro.2012.07.014

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