Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

@article{Spies1991RestoredEO,
  title={Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter},
  author={Thomas Spies and Robert Demars},
  journal={Nature},
  year={1991},
  volume={351},
  pages={323-324}
}
CYTOTOXIC T lymphocytes recognize antigen-derived peptides bound to major histocompatibility complex (MHC) class I molecules with which they assemble in the endoplasmic reticulum or in an undefined subcompartment1–10. There is genetic evidence that the peptides that are products of cytosolic protein degradation are transported into this compartment by a peptide supply factor (PSF), encoded in the MHC class II region11. Like the corresponding genes RING4, HAM1 and mtpl (refs 12–14), PSF is… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 100 extracted citations

Similar Papers

Loading similar papers…