Restorative effects of zinc and selenium on cadmium-induced kidney oxidative damage in rats.

@article{Xiao2002RestorativeEO,
  title={Restorative effects of zinc and selenium on cadmium-induced kidney oxidative damage in rats.},
  author={Ping Xiao and Xiaodong Jia and Wei-Jian Zhong and Xi-peng Jin and Gunnar Nordberg},
  journal={Biomedical and environmental sciences : BES},
  year={2002},
  volume={15 1},
  pages={
          67-74
        }
}
OBJECTIVE To investigate whether cadmium-induced oxidative stress in the kidney is influenced by zinc and selenium. METHODS Five groups of rats were maintained: (A) Cd (CdCl2, 400 micrograms.kg-1.day-1 intraperitoneal injection); (B) Cd + Zn (ZnCl2, 20 mg.kg-1.day-1 hypodermic injection); (C) Cd + Se (Na2SeO3, 350 micrograms.kg-1.day-1 via a stomach tube); (D) Cd + Zn + Se; (E) treated with physiological saline as a sham-handled control. The rats were given treatment for a period of 4 weeks… CONTINUE READING