Restorative benefits of transplanting human mesenchymal stromal cells overexpressing arginine decarboxylase genes after spinal cord injury.

@article{Park2015RestorativeBO,
  title={Restorative benefits of transplanting human mesenchymal stromal cells overexpressing arginine decarboxylase genes after spinal cord injury.},
  author={Yu mi Park and Sun Hyup Han and Su ‐ kyung Seo and Kyung Keun Park and Won Taek Lee and Jong Eun Lee},
  journal={Cytotherapy},
  year={2015},
  volume={17 1},
  pages={
          25-37
        }
}
BACKGROUND AIMS Mesenchymal stromal cells (MSCs) promote functional recovery in central nervous system (CNS) injury. Neuroprotective effects of MSCs are being tested in clinical trials for the treatment of CNS injury; however, the underlying mechanisms remain unclear. Arginine decarboxylase (ADC) is a rate-limiting enzyme of agmatine synthesis and is known to exist in the CNS of mammals. The present study investigated whether transplantation of ADC-overexpressing human MSCs (ADC-hMSCs) after… CONTINUE READING

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