Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin.

@article{Lin2008RestorationOV,
  title={Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin.},
  author={Bin Lin and Amane Koizumi and Nobushige Tanaka and Satchidananda Panda and Richard H. Masland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 41},
  pages={
          16009-14
        }
}
The rod and cone cells of the mammalian retina are the principal photoreceptors for image-forming vision. They transmit information by means of a chain of intermediate cells to the retinal ganglion cells, which in turn send signals from the retina to the brain. Loss of photoreceptor cells, as happens in a number of human diseases, leads to irreversible blindness. In a mouse model (rd/rd) of photoreceptor degeneration, we used a viral vector to express in a large number of retinal ganglion cells… CONTINUE READING

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Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration

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