Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones.

@article{Riddell1992RestorationOV,
  title={Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones.},
  author={Stanley R Riddell and Kazuya Watanabe and J. M. Goodrich and Caroline R. Li and Mounzer E. Agha and Philip D. Greenberg},
  journal={Science},
  year={1992},
  volume={257 5067},
  pages={
          238-41
        }
}
The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy for viral infections and tumors in animal models. The application of this approach to human disease would require the isolation and in vitro expansion of human antigen-specific T cells and evidence that such T cells persist and function in vivo after transfer. Cytomegalovirus-specific CD8+ cytotoxic T cell (CTL) clones could be isolated from bone marrow donors, propagated in vitro, and adoptively… CONTINUE READING

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