Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate.

@article{Fukuda1995RestorationOS,
  title={Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate.},
  author={T Fukuda and Daisuke Kitamura and Ichiro Taniuchi and Yoichi Maekawa and L E Benhamou and P. Sarthou and Toshiyuki Watanabe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 16},
  pages={7302-6}
}
The HS1 protein is one of the major substrates of non-receptor-type protein-tyrosine kinases and is phosphorylated immediately after crosslinking of the surface IgM on B cells. The mouse B-lymphoma cell line WEHI-231 is known to undergo apoptosis upon crosslinking of surface IgM by anti-IgM antibodies. Variants of WEHI-231 that were resistant to anti-IgM-induced apoptosis expressed dramatically reduced levels of HS1 protein. Expression of the human HS1 protein from an expression vector… CONTINUE READING

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