Restoration of skeletal muscle leptin response does not precede the exercise-induced recovery of insulin-stimulated glucose uptake in high-fat-fed rats.

@article{Ritchie2011RestorationOS,
  title={Restoration of skeletal muscle leptin response does not precede the exercise-induced recovery of insulin-stimulated glucose uptake in high-fat-fed rats.},
  author={Ian R. W. Ritchie and Roberto A Gulli and Leslie E. Stefanyk and Ewa Harasim and Adrian Chabowski and David James Dyck},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={300 2},
  pages={R492-500}
}
Leptin administration increases fatty acid (FA) oxidation rates and decreases lipid storage in oxidative skeletal muscle, thereby improving insulin response. We have previously shown high-fat (HF) diets to rapidly induce skeletal muscle leptin resistance, prior to the disruption of normal muscle FA metabolism (increase in FA transport; accumulation of triacylglycerol, diacylglycerol, ceramide) that occurs in advance of impaired insulin signaling and glucose transport. All of this occurs within… CONTINUE READING