Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone-(1–34)

  title={Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone-(1–34)},
  author={James F. Whitfield and P. D. Morley and Virginia Ross and Richard J. Isaacs and Raymond H. Rixon},
  journal={Calcified Tissue International},
It is commonly believed that the parathyroid hormone's (PTH's) main function in bone is to stimulate osteoclastic resorption. However, intermittent injections of small doses of PTH holoprotein, but more often its bioactive hPTH-(1–34) fragment, have been shown to stimulate bone growth in animals and humans through their ability to stimulate adenylyl cyclase and not their ability to independently activate a protein kinases-C stimulating mechanism. This anabolic action suggests that PTH might be… CONTINUE READING


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